Medical Student’s Study Indicates
Viruses Inhibit Monocyte Chemotaxis
. DR. JAMES T. CLELAND
Cleland Fund
(Continued from page 1)
Awarded the degree of Doctor of
Divinity by Davidson College and
Glasgow University, he has served as
lecturer, professor and visiting professor
at numerous theological institutions and
universities, and he is the author of The
True and Lively Word, Wherefore Art
Thou Come, Preaching to be Understood
and He Died As He Lived.
Income from the endowment fund,
which already totals more than $95,000,
will provide for distinguished visiting
preachers and musicians, development of
the choral program and the general
enrichment of chapel worship.
In order for the programs to beconfie
fully operative, the sponsoring committee
hopes that the future donations of friends
and colleagues will match the amount
already contributed.
Pledges, which may be made over a
three-year period and are tax deductible,
will count toward Epoch Campaign
giving.
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Duke University for the Cleland Chapel
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FOR SALE-1970 blue Karmann Ghia,
$1,350. Call 286-0726 and ask for Nellie.
FOR SALE-30" Hotpoint electric Drop-in
range, tawny gold, black glass door, plug-in
surface units, dock and four hour timer, $200
firm. Call 477-7543.
FOR SALE-Sears Coldspot air conditioner,
6,000 BTU, $30; Kenmore washing machine,
$60; and dinette set with four chairs, $25. Call
Charlotte Locher at 688-8679.
FOR SALE-Pair of white clinic shoes, just
about new, will sell for $7. Call 682-1371 after
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FOR SALE-Table with four chairs, rediner,
swivel chair, belt vibrator and electric stove
(white). Call 471-1205.
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ORIENTAL ART
There will be an exhibition and sale of
original oriental art including woodblock
prints, etchings, woodcuts and
lithographs in the West Campus Union
BIdg., Rm 101, on April 22 from 11 a.m.
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FOR SALE-Set of Collier's encyclopedias
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FOR SALE-Two fish tanks, one 15 gal.
metraframe with 25 lbs. blue gravel, small
Dynaflo filter, incandescent light hood and
heater for $25, and the other a 10 gal., all glass
tank with 10 lbs. of black gravel and
fluorescent light hood for $12. Also, New
Home sewing machine in cabinet, in good
condition with many attachments, got new one
as a gift, will sell for $50. Call 477-3342
between 8 and 11 a.m. or after 5 p.m.
When a person who is suffering from
tuberculosis is given a skin test for the
respiratory disease, a large red welt
usually appears at the test site.
On the other hand, when the same
person contracts a virus-induced malady
such as measles while suffering from TB,
no welt will appear until the measles have
disappeared.
This phenomenon, well documented in
medical literature, interested a third-year
student in the School of Medicine and her
mentors to the extent that they designed
and conducted experiments which help to
explain it.
Genie Kleinerman of Shaker Heights,
Ohio, found that certain viruses may
inhibit the body's mechanism for
eliminating foreign particles such as
bacteria which can cause a person with a
relatively harmless disease like influenza
to develop "supra-infections" which may
result in death. "Supra-infections" are
those which occur while another
infection is already in progress in a
patient.
The 24-year-old future Pediatrician,
who was enrolled in Duke's virology
study program under Dr. Ralph
Snyderman, associate professor of
medicine, and Dr. Charles Daniels,
assistant professor of pathology,
presented the results of the experiments
at the annual meeting of the Federation
of American Societies for Experimental
Biology in Atlantic City, N.J., yesterday.
Her presentation was 'entitled
"Depression of Monocyte Chemotaxis by
Virus."
The viruses used in the study were
Herpes simplex and influenza. Herpes
simplex has been linked to such disease
conditions as cancer of the cervix, genital
lesions, meningitis, encephalitis and fever
blisters.
Ms. Kleinerman and her advisors
reasoned that viruses must somehow
prevent monocytes—white cells which
attack and engulf foreign particles or
"antigens" such as bacteria-from
responding to the chemical message sent
out by another kind of cell called
lymphocytes when foreign bacteria has
been detected in the body.
The experiment involved placing
isolated monocytes which had been
removed from human blood by a test
tube separation procedure and the
chemical message or "chemotactic
factor" at opposite ends of a small plastic
chamber designed by Snyderman to
measure monocyte movement. The
monocytes were released on a tiny filter
with microscopic openings at one end of
the chamber, and the chemical, also
separated from human blood, was poured
into the other opening.
Healthy cells were able to squeeze
through the openings in the fitter when
the chemical stimulus was added in a
biological fluid.
The investigators found that
monocytes which had been subjected to
Herpes simplex and influenza viruses
responded to the "call" of the chemical
only 25 per cent as well as did the
healthy cells. Hence their theory that
viruses weaken the body's natural
defenses against diseases which are caused
by non-viral pathologic agents gained
experimental support.
The red welt which appeared during
the tuberculosis test showed that the
bo;Jy was actively fighting the disease.
When the welt was absent in patients
known to have tuberculosis, the body's
"immune system" was not working as it
should have. The Duke investigators'
work indicates that viruses are the culprit.
New Ward
(Continued from page 1)
wards including pediatric, psychiatric,
acute care and remote ambulatory units
will only be possible under exceptional
circumstances and by specia
arrangement.
"During the last four weeks, meeting
and communications with medical staff
and hospital employees have emphasized
the procedural changes which the unit
introduces," said Kramer.
"Everything possible has been done to
create in the Discharge Unit a
comfortable environment for patients
awaiting departure, and the role of
physicians, nurses, DTO's, housekeepers,
and Business Office and admission
personnel will be decisive in the success
of the entire program," he added.
A special brochure listing hospital
discharge procedures will be distributed
to patients on the evening prior to their
departures.
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