2
Kelley Gets Grant To Study Relation
Between Enzyme ADA, Birth Defect
A researcher at the medical center has
been awarded a $44,332 grant from the
National Foundation-March of Dimes to
study the possible connection between a
rare inherited enzyme deficiency and a
fatal birth defect.
Dr. William N. Kelley, professor of
medicine and chief of the Division of
Rheumatic and Genetic Disease will
attempt to find what role the enzyme
ADA (adenosine deaminase) plays in
normal white blood cells and whether
infants with the disease, which is called
severe combined immune deficiency
(SCID), lack the enzyme completely,
h9ve a defective form of it or cannot
convert certain sub-types of it to meet
the needs of cells which fight disease.
Physicians who have seen patients with
SCID have already established that the
immune defenses of these patients are so
defective that even a routine vaccination
or mild skin fungus may lead to
overwhelming infection. Infants affected
by SCID seldom live more than a few
months.
Recently, researchers have found that
a number of SCID patients lack the
enzyme ADA, which is particularly
abundant in the white blood cells of
healthy subjects. Because of this
discovery and because of the relative
rarity of both conditions, many experts
now believe that there may be a direct
relationship between the deficiency and
the disease.
That is, the enzyme may be essential
for white blood cells to perform their
task of removing disease carrying agents
from the blood stream.
The lack of ADA is the first inherited
metabolism error to be linked with a
proven immune system defect. If Kelley's
studies are successful, medical science
may soon know the mechanism by which
the enzyme deficiency causes the disease
and gain valuable information about
immune system disorders in general.
Working with Kelley are Dr. Martin
Van der Weyden, a research fellow in the
division; Dr. Dina Fischer, a post-doctoral
fellow in genetics; and biochemistry
graduate student Sara Singer.
COMPUTER COURSES
The Computation Center is offering
several free, non-credit computer courses
during the month of July. They are open
to Duke faculty, students, all employees,
and members of the families of any of
these. Also, employees of Duke-related
non-profit organizations, such as the V.
A. Hospital, are eligible.
The courses will meet from 4-5 p.m.
each weekday, Monday through Friday,
and will be taught by members of the
Computation Center staff. Most of the
courses assume little or no prior
knowledge of computers. The subjects
taught will be:
Introductory Concepts & Facilities,
July 8-10; Beginning PL/I, July 11-23;
Beginning FORTRAN, July 11-23; JCL
(Job Control Language), July 24-August
2; Statistical Packages, July 24-August 2;
and General Terminal Usage, July
24-August 2.
If you are interested in any of these
courses, please call Ext. 4009 for more
information or to enroll.
Employe Relations Office Moves
The Medical Center Employe
Relations Office has moved to a new
location. Its headquarters is now located
in the Medical Center Personnel Office,
Room 1160 in the main hospital.
The telephone number. Ext. 6037,
remains the same.
Trading Post
You may send ads to "Trading Post,"
Box 3354, Hospital. Ads are printed free,
but we do not advertise real estate,
personal services or commercial
enterprises. Please give your home
telephone number. Duke extensions will
not be listed.
FOR SALE-1868 Honda C70M motorcycle,
$160 and helmet, $10; Kenmore washing
nnachlne, \whlte, top loading, works perfectly,
$65; Sears Ironstone dinner-service for eight,
$25; stainless steel tableware for eight. $12;
blender, $10; 3-speed beater, $3.50; misc.
children's toys and equipment and other
household items. Call 489-2800.
FOR SALE-Triple bunk beds, complete set
$50 or individual beds $20 each. Also violin
with case, $30; trumpet with case, $15; sleeping
bag, $5; and 20-inch bicycle, $20. Call
477-6253.
FOR SALE-Wooden fishing boat, 13', with
Sears trailer, 5 hp outboard motor, carpeted,
freshly painted, with canopy, life jackets, and
anchor and paddles, $400. Call 688-5825 after
5 p.m.
FOR SALE--King-sized bed in good
condition, must sell. Call 732-8873 any
evening.
^^VitGucom
i$ published weekly for Duke
Universitv Medical Center employees, faculty,
staff. stiider)ts arKi friends by the Medtcal
Center's Office of Public Relations, Joe Sigler,
director: Miss Annie Kittretl, secretary.
Co-Editors
DAVID WILLIAMSON
DALE MOSES
Pubfic Relations Advisory Committee: Sam A.
Agnello. audiovisual education; Dr. Robert
Anderson Jr., surgery; James L. Bennett Jr., vice
president's office; Wayne Gooch, personrwl; Dr.
Athos Ottoler>ghi, physiology and pharmacology;
Richard Peck, hospital administration; Miss
Isabelle Webb, RN, nursing service; Dr. Tom C.
Vanaman, microbiology and immunologY.
J)
AWARD FOR RESEARCH REPORT—Dx. Edward M. Mullin Jr., (right) a resident in
urology, receives the Dr. Grayson Carroll Award from the St. Louis urological pioneer
for whom it was named. The award, established by Mallinckrodt, Inc., is given for an
outstanding report on research in urology and was presented during the annual
meeting of the American Urological Association in May. Mullin's paper, with
contributions by Dr. Robert A. Bonar and Dr. David F. Paulson, was “Acute Tubular
Necrosis: An Experimental Model Detailing the Biochemical Events Accompanying
Renal Injury and Recovery." Mullin read the paper at the annual meeting in St. Louis.
Rare Old Books
(Continued from page 1)
FOR SALE-RCA Whirlpool refrigerator, 7
years old, in good condition, best offer, you
move it. Call 477-0845.
PATIO SALE-Glass and china ornaments,
rugs, and potted plants. Saturday, 10 a.m. until
2 p.m., 28 Lebanon Circle off Guess Rd. by the
Eno River.
FOR SALE-1971-Ford Galaxie, two-door,
hardtop, white, air conditioning, available at
the end of June, very reasonable, $1,500. See
Richard Hamer in the Anatomy Dept, or call
477-1820 after 6 p.m.
FOR SA LE--Mahogany Hepplewhite
drop-leaf dining table, $275; English Regency
dining chairs, mahogany and cane, brass
rosettes, very elegant, set of six, $1,500;
English mahogany Sheraporn side table, circa
1820, one drawer, brass handles and feet, $225;
and eight Stuart wine glasses, $50. See Richard
Hamer in the Anatomy Dept, or call 477-1820
after 6 p.m.
FOR SALE-Ladies dresses, sizes 20Vi and
22%. Also 1964 Ford Fairlane, 2-door,
automatic transmission, light blue, excellent
condition. Call 477-0020 after 6 p.m.
FOR SA LE--3-speed G.E. fan, new
condition; 4-speed Columbia stereo, cabinet
model; odd size storm windows; and TV stand.
See at 101 E. Maynard Ave. or call 477-5011.
FOR SALE--Emerson 8,000 BTU air
conditioner, 110 volt., excellent condition. Call
383-5007 evenings.
FOR SALE-1968 Chevy Caprice, new tires,
new heavy duty shocks, new ball joints, new
a.c. system, green with black vinyl top,
four-door, V-8, in good condition, family car,
best offer over $600. Call 286-1841 or
477-0520 after 6 p.m.
FOR SALE-21 ft. Prowler, self-contained
camper, used only 6 times, 1972 nrodel, sleeps
8, separate bath with tub, $3,200 or best offer.
Call 477-8080 after 5 p.m.
YARD SALE--At 415 Hammond St.,
‘Saturday, June 22 from 10 a.m.-4 p.m. (rail) date
June 29). Sale includes good used clothing,
furniture and appliances.
that are part of the collection.
The Barchas Center will have a
director appointed from the Duke faculty
and an editor-in-chief of the collection. A
six-member committee, on which the
Barchases will serve, will manage and
guide the collection, including future
acquisitions.
The oldest book in the Barchas
Collection is one of the first
encyclopedias ever published—a first
edition of the "Etymologiae" of Bishop
Isidore (Isidorus Hispalensis) of Seville. It
was written in the 7th Century and was
first published in 1472.
The book contains the first printed
astronomical diagrams, the first T-map
showing the relation of the continents
and a chapter on medicine.
A sampling of other volumes in the
collection includes these:
—One of the world's finest copies of
the first edition, published in 1543, of
the "De Revolutionibus" of Copernicus,
in which he proposed his revolutionary
heliocentric theory that the earth revolves
around the sun.
—A copy presented to Sir Isaac
Newton by the great Dutch scientist
Huygens of Huygen's principal work,
"Horologium Oscillatorium," published
in 1673.
—The first published edition of
Euclid's Geometry, published by Ratdolt
in Venice in 1482. The book has now
gone through more than 1,000 editions.
The collection contains almost all of
the published papers of Albert Einstein,
as well as many of the published works of
Galileo, Kepler, Tycho Brahe and Willard
Gibbs.
Among the medical classics in the
collection are first editions of Thomas
Addison's "On the Constitutional and
Local Effects of Disease of the
Supra renal Capsules" (1855); Vieussens'
"Neurographia Universalis" (1684):
Semmelweis on childbed fever (1861);
Mascagni's "Vasorum Lymphaticorum," a
tall folio atlas published in 1787; and a
presentation copy of George Berkeley's
"An EsS^y, Towards a New Theory of
Vision" (T709)»
The collection also contains a good
copy of Fuch's herbal of 1542 and
periodical volumes containing Ephraim
McDowell's 1817 report of the first
successful ovariotomy and the 1873
preliminary paper of Freud and Breuer on
the unconscious mind.
Barchas credits his wife, Cecile, with
stimulating, first, his interest in science,
and later with setting them on their
course of rare-book collecting.
The details of his law practice, and
particularly the demands of his trial
work, which included Hollywood divorce
actions, reached the point, Barchas
recalled, that his wife suggested that "we
needed to get a different perspective of
life.
"Cecile suggested that it might be
desirable to read a good book on
astronomy," he recalled, "and she
presented me with such a book, "The
Universe Around Us" by James H. Jeans.
That seemingly insignificant, initial
investigation of astronomy, Barchas said,
"made me realize what a vast panorama
the world of science is. We gradually
bought and read more books on
astronomy, until the time came when we
purchased our first rare book."
That was in the mid-1940s and the
book was "Astronomy Explained Upon
Sir Isaac Newton's Principles," a third
edition published in 1761 and written by
James Ferguson, a self-educated Scot
who, as a shepherd boy, had studied the
stars.
"We were so fascinated," he said,
"when we realized that here was a world
opening before us that we needed to
explore—the world of rare books in
science—that we've simply kept it up ever
since.
"With* the leadership and excellent
faculty at Duke, and with its strong
tradition in both science and history, it
was only natural that we should choose
Duke as the ultimate home for these
books," Barchas said.
G. S. T. Cavanagh, director of the
Medical Center Library, personally
supervised the packing and shipping of
the Barchas Collection to Duke.
Until the new medical library is
completed next year, the collection will
be housed in Perkins Library, where
cataloging will begin.