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12-THECMOUN TIMES
OBESITY
LINKED'Tp
HORMONE
By Ginger Rutherford
The study of fat rats may
seem like a strange preoc
cupation but the results may
help us better understand the
function of one of the hor
mones found in our bodies.
This hormone is called Beta
endorphin. It was discovered
by Dr. Choh Hao Li, director
. of the Hormone Research
Laboratory of the University
of California in San Fran
cisco, and has been mainly
recognized as the body's
natural opiate. The hormone
is secreted by the pituitary
gland which is located at the
base of the brain.
The report of a study
published in Science concerns
the effect that lendorphin
might have on overeating
and obesity. Research , by
Margules, Lewis, Shibuya
and Pert was conducted us
ing genetically obese rats and
mice and their lean litter
mates.
It had been previously
found that the opiates, 0 -endorphin
and morphine, in
duced overeating in
laboratory animals. It , was
also shown that the obese
animals had two times more
naturally occurring ? -endorphin
in their pituitaries
than their lean litter mates.
Therefore, the study was
conducted to find out if the
agent that stimulated
overeating was actually the
0 -endorphin or some other
substance. To do this both
fat and thin rats and mice
were injected with an opiate
repressant, naloxone. Nalox
one stops the opiate qualities
of -endorphin. If the opiate
qualities were stopped, 'then
what effect would this have
on the feeding behavior of
the animals?
The results were that doses
of naloxone from .5 mgkg
to 5 mgkg suppressed
overeating in obese mice and
rats. This effect was tea
times greater in the obese
animals than it was in their
lean litter mates. Thus it was
concluded that there is a rela
tionship between high levels
of P-endorphin and obesity
at least in the rats and mice
tested.
It is thought that , 0-en- .
dorphin when released Into
the body from the pituitary
gland stimulates opiate
receptors in the intestinal
tract. When this happens
. feeding behaviors are
stimulated. Thus an excess of
-endorphin being received
by the opiate receptors can
lead to overeating through
: over-stimulation.
When naloxone is used to
suppress the effects of en
dorphin, the opiate receptors
re not activated to produce
feeding behaviors. A similar
result may be achieved by the
- surgical removal of the
opiate receptors. Often peo-
. pie who have intestinal by-
pass surgery lose the urge to
overeat. Since the surgery
sometimes removes an area
of the intestine that contains
, many opiate receptors, it it
possible that the effect of 0
endorphin in overeating may
be reduced by the absense of
some of the receptors.
(Picparukn of (hit ankle u aide poui
bk by iruu Uom NSF. Tlx viewt of iMt
article arc those of the author and do not
rwceuarily represent those of NSF.) ' '
Wachovia Teller
II Registers
Nine Million
Transactions
Wachovia Bank anc1
Trust Company's network
of Teller II automated
teller machine registered a
record nine million tran
sactions in 1980, up from
about six million transac
tion during 1979, accor
ding to James T. Brewer,
manager of the bank's
Retail Banking Depart
ment. thirty-three automated
teller machines were add
ed tg the statewide net
. work during the year, in
cluding twelve in com
munities where Teller U
was introduced for the
first time. Wachovia con
lined to have the largest
automated teller machine
network it) North
Carolina with a total of M
machines in 34 cities.
The monthly average ol
transaction volume , pet
machine was 8,400 which
is about double the. na
tional average, Brewer
said.
At the end of 1980, ap
proximately i ' 425,000
Wachovia customer .held
4 Teller II banking card
This number increased by
about 75,000 from 1979.
SAT., MARCH 21.1581
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